Chapter 16 Dragees. Granules.
Drops.
Drops - firm dosed out LF for internal application,
Received by repeated naslaivanija (drazhirovanija)
Medicinal and auxiliary substances on sugar granules
(krupku). The drops have the spherical form, weight 0,1 - 0,5ã. As
The drops issue difficultly tabletiruemye medicinal substances.
The drops allow to hide unpleasant taste of medicinal substance,
To reduce their irritating action, to protect from influence
External factors. However in this LF it is difficult to provide accuracy
Batchings, raspadaemost in required terms, fast
Liberation of medicinal substances. The drops are not recommended
To children. Taking into account above stated, this LF does not concern to
Perspective.
Technology: industrial production of drops is carried out in
Drageeing boilers (obduktorah). Process of reception of drops
It is similar to technology of a covering of tablets drageeing
Shells. As auxiliary substances apply sugar,
Starch, wheat flour, magnesium a carbonate, etilTS, atsetilTS, NaKÌÖ,
Talc, gidrogenizirovannye fats, an acid stearin, cocoa,
Chocolate, food dyes and varnishes.
Granules (sugar krupka) sift through a sieve with calculation,
That in 1 g them contained about 40, load in rotating
The boiler also make consecutive escalating until
All materials will not be spent.
Obduktor represents the rotating boiler of the oval form,
ukreplennyj on inclined to a shaft. Speed of rotation of the boiler from 20 up to
60 rev/min. Loading obduktora should make 1/5 - 1/6
Volume. At the greater loading a tablet can collapse under
Weight of the rotating weight, at smaller to be used up for the bill
Intensive hashing inside the boiler.
For drawing each subsequent layer a surface of drops
Humidify a sugar syrup and in regular intervals sprinkle all over again with a flour,
And in some minutes - magnesium a carbonate. After 25 - 30 ' in
The boiler submit filtered air, podogretyj up to t = 40-
50? C. The weight dries up through 30 - 40 minutes. Operation repeat 2 - 3
r.
Prepare testoobraznuju for the weight consisting of a flour and a syrup
Sugar (1 kg of a flour on 2 l a syrup), here add
Medicinal substances.
Water poslojno, sprinkle magic with a carbonate. Submit hot
Air for 30-40 minutes. Operation repeat 2 - 3 times.
At the end of process the boiler rotate without escalating and receive drops
With a brilliant smooth surface. For glossing add
Wax.
Granules.
It LF as grains of the round or cylindrical form,
A containing mix of medicinal and auxiliary substances (sugar,
Lactose, starch, glucose, talc, etc.). They are easy for swallowing,
It enables to apply them in pediatric practice.
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