Pharmaceutical technologies | THE CHAPTER 15

Chapter 15  Prospects of development Technologies of tablets. Napressovannye coverings. Trituratsionnye Tablets.
 Prospects developments of technology of tablets.
Multilayered tablets allow to combine medicinal substances, Incompatible on physical and chemical properties to prolong Action of medicinal substances to adjust sequence Them vsasyvanija in the certain time intervals. For them Manufactures are applied by cyclic tabletochnye of the machine. The medicinal substances intended for various layers, Move in a feeder of the machine from the separate bunker. In a matrix on Turns the new medicinal substance, and bottom is filled The punch falls all below. Each medicinal substance has The painting, and their action it is shown consistently, in The order of dissolution of layers. For reception of layered tablets Various foreign firms issue special models RTM, in Particulars firm " V.Fette " (Germany).
Frame tablets (or tablets with an insoluble skeleton) - for Their receptions use the auxiliary substances forming Mesh structure (matrix) in which it is switched on medicinal Substance. Such tablet reminds gubku, which time Are filled with soluble medicinal substance. Such tablet not Breaks up in a gastroenteric path. Depending on The nature of a matrix she can nabuhat and slowly be dissolved or To save the geometrical form during all stay in An organism also it is deduced constant as porous weight, in Which time are filled with a liquid. Frame tablets concern to To preparations of prolonged action. Medicinal substance from Them it is liberated by washing away. Thus his speed Liberation does not depend on the maintenance of enzymes in surrounding To environment, from its size rN also remains enough constant on To a measure of passage of a tablet through a gastroenteric path. Speed of liberation of medicinal substance, define such Factors, as the nature auxiliary and solubility Medicinal substances, a parity of medicines and forming A matrix of substances, porosity of a tablet and a way of its reception.
Auxiliary substances for education of matrixes subdivide on gidrofilnye, waterproof, inert and inorganic.
Gidrofilnye matrixes - from nabuhajushchih polymers (gidrokolloidov): gidroksipropilTS, gidroksipropilmetilTS, gidroksietilmetilTS, metilmetakrilata, etc.
Waterproof matrixes - (lipidnye) - from natural voskov or from Synthetic mono-, di-and triglitseridov, hydrogenated Vegetable oils, fat maximum spirits, etc.
Inert matrixes - from insoluble polymers: etilTS, Polythene, polimetilmetakrilat, etc. For creation of channels in A layer of polymer, insoluble in water, add water-soluble Substances (PEG, PVP, lactose, pectin, etc.). Being washed away from a skeleton Tablets, they create conditions for gradual allocation of molecules Medicinal substance.
For reception of inorganic matrixes use nontoxical Insoluble substances: Ñà2ÍÐÎ4, ÑàSO4, BaSO4, aeroforces, etc.
Frame tablets receive direct pressing of a mix Medicinal and auxiliary substances, pressing Whether microgranules of microcapsules of medicinal substances.
Tablets with ionitami - prolongation of action of medicinal substance Probably by increase in his molecule at the expense of sedimentation, on and- About pitch. The substances connected with and about pitch, become Insoluble, and clearing of medicinal substance in A digestive path it is based only on an exchange of ions. Tablets With ionitami support a level of action of medicinal substance Within 12 hours.

We offer you our link base:   OUR WEB SITES  and  USEFUL LINKS.