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Introduce to you new tablet press "Tabletpress 6000S" :
Technologies of pharmaceutical manufacture tablets:
Tablets is the firm dosed out medicinal form received
Pressing medicines, it is usual with application of auxiliary substances, or
Formation special masse.
All now in use kinds tablet preparations in
Dependences on their purpose and ways of application share on the following
Groups:
1. The tablets used peroralno. Are soaked up by a mucous membrane
A stomach or an intestines. Are the most widespread kind
tableted preparates.
2. Polygonal, cylindrical or the oval form the tablets used
For preparation of rinsings, syringings and other solutions used with
The various purposes in medical and pharmaceutical practice.
3. Asepticheski the prepared tablets used for reception
растворов.
4. The tablets which are soaked up by a mucous membrane mouth.
5. The tablets used for implants.
6. The tablets having sweet taste. Are applied as chewing
tablets.
7. Pressed urethral, vaginal and rekta medicinal forms.
On a way of preparation of a tablet are subdivided into two types-
Pressed and trituratsionnye. The first type includes overwhelming majority
All issued tablets, the second makes only 1-2 % of the general manufacture
tabletirovanyh preparations. The pressed tablets the Pressed tablets is
The firm dosed out medicinal form received by pressing. Tablets
, prepared by a method of pressing, have the various sizes, the form and
Weight. The most widespread form is the cylinder with biconvex
A face surface and rounded edges, or oval диск.
Such form provides the maximal durability of a tablet at minimal
Weight and the size, creates the certain convenience at semi-automatic and
To automatic packing and as facilitates proglatyvanie. Tablets should
To have the correct form, integral, without vyshcherblennyh places of edge. Them
The surface should be smooth and uniform.
Diameter of tablets changes from 3 up to 25 mm, tablets in diameter over 25 mm
Are called as briquettes and are made on special briquetting
Machines. Tabletpress.ru offers you a desktop tablet press "
Tabletpress 6000S" for manufacture of tablets dimetrom from 5 mm up to 13 мм.
Most often there are tablets in diameter from 7мм up to 13 mm. On tablets
In diameter more than 9 mm render to risk (notch) which facilitates division
Tablets on two parts. The tablets, the having two notches put
Perpendicularly one another, can be easily divided into four enough
Equal parts. It is done basically for convenience of reception of tablets by children,
As allows to reduce a dosage of working substance. Height of tablets
Should make 30-40 % of their diameter. The weight of tablets varies in rather
Wide limits - from 0,05 gramme up to 20 gramme - also it is defined by the main thing
In the image a weight dosage medicinal substances.
Except for medicinal substance, on weight of a tablet render certain
Influence and other components which are almost always included in its structure, named
Auxiliary substances. Auxiliary substances If medicinal
The substances contained in a tablet, provide its therapeutic effect,
That auxiliary substances carry out double function: on the one hand
Help (from here and the name "auxiliary") is easy for education
doziruemoj and the pressed weight, on the other hand - provide clearing
Medicinal substance from a tablet with necessary speed, generally
Determined by time raspadaemosti tablets.
Poroshkoobraznye medicinal substances, behind very small exception (
Sodium chloride and jodid, antipirin, geksametilentetramint and some other
), are not capable to form in press of a tablet of satisfactory quality.
In this connection almost all tablets issued farm. The industry,
Necessarily contain the certain quantity of auxiliary substances.
Certainly, always aspire to, that the maintenance of these substances in
To a tablet was minimal, for in relation to an organism of the patient many from
Them are балластом.
The total of auxiliary substances should not exceed 20 % of weight
Medicinal substance. Exceptions make thinners, quantity
Which in tablets it is not normalized. The quantity of talc should be no more
3 %, a stearin acid, stearata calcium or magnesium - no more than 1 %, the twin
-80 no more than 1 % of weight of a tablet, except for separate cases. All
The auxiliary substances used in manufacture of tablets, in
Dependences on their purpose are subdivided into the following groups:
The thinners loosening, sliding and greasing, binding.
DILUTERS
Thinners are the substances entered in propisi (structure) tabletiruemyh of weights
With the purpose of achievement of necessary weight tableted preparations at
The insignificant maintenance of a working component. As thinners
Apply starch, sveklovichnyj sugar, dairy sugar, glucose, calcium
Hydrophosphate, magnesium a hydrocarbonate, magnesium okis, calcium sulfate, attracts,
Sodium chloride, kaolin, magnesium a carbonate the basic, sorbite, urea and t.d For
Each kind of tablets select the certain quantity auxiliary
Substances which should provide appropriate quality of ready tablets.
The cheapest and accessible, from available thinners remain,
Starch, glucose and sugar.
LOOSENING SUBSTANCES
Loosening substances are the connections providing mechanical
Destruction (raspadenie) tablets in a stomach or an intestines with digestive
Juices. Action depends on time raspadaemosti tablets medicinal
Substances. Bad raspadaemost a tablet can cause a delay or
Decrease in therapeutic action of a preparation or it kumuljatsii in an organism.
In this connection the test on raspadaemost has received in pharmaceutics special
value.
On the mechanism of destroying action all loosening substances can be divided
On three groups:
1. Destroying a tablet at the expense of swelling (ultraamilopektin, an agar - agar,
Gelatin, formolzhelatin, an alginic acid, alginat sodium, metiltselljuloza,
natrium-carbonmethylcellulose) 2. Destroying a tablet for the bill gazoobrazovanija - so-called sparkling
Mixes (for example mixes of a hydrocarbonate of sodium with citric or vinnokamennoj
asid )
3. Improving wettability and water penetration of a tablet (
Surface-active substances - for example twins, speny, sodium laurilsulfat,
And also kraxmal.)
SLIDING AND LUBRICATED
Such substances enter in structure tabletiruemoj weights for improvement of properties
Fluidity and sliding. Experts farm. Manufactures define a kind and
Quantity of sliding and greasing substances by practical consideration in everyone случае.
The given substances are subdivided into three groups:
1. The substances improving mobility, flowability granuljata (tabletmassy), (
Starch tonkoizmelchennyj, talc, polietilenglikoli, low-fat dairy
A powder, a boric acid, aeroforces, silicate of aluminium, a mix of sodium benzaata and
Sodium ацетата.)
2. Antiagdezionnye (protivoprilipajushchie, actually greasing)
A stearin acid, paraffin, tserezin, silikonovye oil )
3. Substances of the mixed action (improving flowability and reducing
prilipaemost): mainly stearaty calcium, magnesium,
BINDING
(sticking together substances). Svjazavajushchie substances add in tabletiruemuju
Weight for increase in durability of granules or tablets. All of them should possess
Connecting ability to not worsen raspadaemosti tablets, to be
Compatible with medicinal substances and indifferent for an organism, and
Also to not be expensive and complex in application.
Connecting substances enter in taleturuemuju weight in two ways: dry and
Damp (i.e. as a powder or as a solution). The choice of a way depends
From physical and chemical properties tabletiruemyh substances. As connecting
Components tabletiruemoj weights apply various gum and pitches,
polietilenglikoli, an alginic acid and its salts, polivinilpirrolidon and
The polyvinyl spirit, derivative cellulose (etiltselljuloza, metiltselljuloza,
Sodium - karboksimetiltselljuloza, gidroksietiltselljuloza as water or
spirtovyh solutions), gummiarabik, krahmalnyj paste, tragakant, an agar,
Casein, solutions of pectin, zeina, ultraamilopektina, various nabuhajushchie
Clay minerals.
Apply also mixes of several substances, for example 5-10 % a solution of gelatin in
63,3 % ethanol with addition of 1-3 % of glycerin or sorbite. In domestic
To practice apply water, etilovyj spirit of various concentration, krahmalnyj
Paste of 3-15 % of concentration, a sugar syrup, solutions of glucose and gelatin.
Usual solvent - water. But is the most popular as binding
Substances on farm.predprijatijah - 5 % krahmalnyj paste.
To read the full version about technology
Pharmaceutical manufacture of medicines in section " TECHNOLOGIES "
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