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Introduce to you
The full information în " Granuljator-30 " :
Granulation or technologies pharmaceutical
Manufactures of granules:
Practical use Granulator-30.
You can use Granulator-30 for dry and damp granulirovanija
Powder weights in pharmaceutical manufacture. Use is possible
Granulator-30 in powder metallurgy, chemical and the food-processing industry.
Theoretical materials devoted to reception of granules on Granulator-30. (
To read before to start to work)
Granulating.
It is process of transformation poroshkoobraznogo a material in grains certain
Sizes that is necessary for improvement of flowability tableting for a mix and
Its prevention splitting.
Granulating can be "DAMP" and «DRY».
The first kind Granulating is connected to use of liquids - solutions
Auxiliary substances; at dry Granulating to the help moistening
Liquids either do not resort, or use them only on one certain
Stages of preparation of a material to tableting.
DAMP Granulating will consist of the following operations:
1) Crushing of substances in a thin powder;
2) Humidifying of a powder by a solution of connecting substances;
3) Wiping of the received weight through net;
4) Drying and processings Granulate.
1. Minuting.
This operation usually spend in spherical mills. A powder sift through
A sieve ¹ 38.
2. Humidiation.
As connecting substances I recommend to apply water, spirit, sugar
A syrup, a solution of gelatin and 5 % krahmalnyj paste. Necessary quantity
Connecting substances establish by practical consideration for everyone tableting
Weights. For this purpose that the powder in general was granulated, he should be
It is humidified up to the certain degree. Sufficiency of humidifying judge so:
A small amount of weight (0,5 - 1ã) compress between big and index
A finger; formed "flat cake" should not stick to fingers (excessive
Humidifying) and to be scattered at falling from height 15 - 20 sm (insufficient
Humidifying). Humidifying spend in the amalgamator with S (sigma) - figurative
Blades which rotate with in the various speed: a lobby - with a speed
17 - 24ob/mines, and back - 8 - 11ob/mines, blades can rotate in return
The party. For oporozhnenija the amalgamator the case of it overturn also weight
Push out with the help of blades.
3. Granulating (reception of granules).
Granulating make by wiping the received weight through a sieve 1-
5ìì (¹ 20, 40 and 50) Apply penetrative a sieve from stainless steel, a brass
Or bronze. The use tkannyh wire sit in avoidance is not supposed
Hits in tabletochnuju weight obryvkov a wire. Granulating make
With the help special protirochnyh machines - Granulators (an example
Granuljator-30). In the vertical punched cylinder fill
The granulated weight also wipe through apertures with the help springing
Blades.
4. Drying and processing of granules.
Ready granules rassypajut a thin layer on pallets also dry sometimes
On air at a room temperature, but is more often at temperature 30 - 40ºC in
Drying cases or drying premises. Residual humidity in granules
Should not exceed 2%.
We have considered operations of a method damp granulirovanija by wiping or
prodavlivanija. Usually operations of mixing and uniform humidifying
poroshkoobraznoj mixes various granulating solutions combine and
Spend in one amalgamators. Mixing is provided at the expense of vigorous
Compulsory circular hashing particles and colliding their friend with
The friend. Process of hashing for reception of a homogeneous mix on structure
Lasts 3 - 5 minutes. Then to preliminary mixed powder in the amalgamator
The granulating liquid moves, and the mix mixs up 3-10 more minutes.
After end of process granulirovanija open the unloading valve, and
At slow rotation of a scraper the ready product gets enough sleep.
Time of drying in drying cases reaches 20 - 24 hours.
If operations damp granulirovanija are carried out in separate devices,
After drying granules operation dry granulirovanija follows. After drying
A granule does not represent uniform weight and often contains komki from
slipshihsja granules. Therefore granules repeatedly acts in protirochnuju the machine.
After that from granules eliminate the formed dust.
As the granules received after dry granulation, have rough
A surface that complicates further them vysypanie from loading voronki
In process tabletirovanija and besides granules can stick to a matrix
And to punches tabletpressa, that causes, besides infringement of weight, defects in
Tablets, resort to operation of "dusting" granuljata. This operation
It is carried out by free drawing it is thin the crushed substances on
A surface of granules. By dusting in tabletmassu enter sliding and
Loosening substances.
DRY Granulating.
In some cases if the medicinal substance decays at presence
Waters, resort to dry granulirovaniju. For this purpose from a powder press
Briquettes which then grind, receiving krupku. After elimination from a dust
krupku tabletirujut. Now under dry granulirovaniem understand
A method at which poroshkoobraznyj a material subject initial
To condensation (pressing) also receive granules, which then tabletirujut-
Secondary condensation. At initial condensation in weight enter dry
Sticking together substances (MTS, KMTS, PEO), providing under pressure coupling
Particles as gidrofilnyh, and waterproof substances. It is proved suitability for
Dry granulirovanija PEO in a combination to starch and talc. At
Use of one PEO the weight sticks to punches.
Connecting substances
Are entered in a dry kind or in a granulating solution in structure of weights for
tabletirovanija at granulirovanii for maintenance of durability of granules and
Tablets. At dry granulirovanii add a small amount
Communicating substances, for example cellulose or polietilenglikol.
At damp granulirovanii there is a rule: if it is required to add
A small amount of a dampener connecting substances enter in a mix in
A dry kind, if quantity of a dampener big, connecting substance
Enter as ðàñòâîðà.
Solubility of connecting substance also influences a choice of a way
His introductions. As connecting substances apply pure solvents (water,
Ethanol) as they in part dissolve tabletiruemyj a material; natural
Gum (an acacia, tragakant), gelatin, sugar (as syrups konts. 50 - 67 %),
krahmalnyj the paste, derivative cellulose, an acid alginic and alginaty.
Researches have shown, that with increase in concentration of a solution connecting
Substances worsens raspadaemost tablets and speed of liberation
Medicinal substance. It concerns to such substances, as krahmalnyj
Paste, Na KMTS, polietilenoksid and gelatin. As to PVP, increase
His quantities are improved with liberation of medicinal substance. This is possible
To say and about alginat sodium. Hence, for everyone tabletiruemogo
A material it is expedient to select optimum quantitative and qualitative
Structure of connecting substances, that, having received the best mechanical properties
granuljata and tablets to provide at the same time required them splitting and
Speed of liberation of medicinal substance.
The Substances promoting slide.
By the nature sliding substances can be broken on two groups:
1) fats and zhiropodobnye substances: the paraffin, hydrogenated vegetative
Fats and the oils - cocoa added in quantity up to 2 %, stearaty calcium and
Magnesium, a pure stearin acid (≤ 1%).
2) powdery substances: talc, starch and tvin-80.
Talc in granuljat add no more than 3 % since he operates razdrazhajushche on
Mucous membranes. Poroshkoobraznye substances find the greater application, than
Fatty as the last are reflected in solubility and chemical
Stability of tablets. Poroshkoobraznye sliding substances are entered
Dusting granuljata.
On the functions sliding substances share on 3 groups: providing
The sliding, greasing and interfering sticking. They provide
The uniform expiration tabletiruemyh weights from the bunker in a matrix, that
Guarantees accuracy and a constancy of a dosage medicinal âåùåñòâà.
Greasing substances promote the facilitated pushing out of tablets from
Matrixes, preventing education of scratchs on their sides.
Anti-stick substances prevent sticking weight to walls of punches and matrixes, and also
slipanie chastichek with each other.
One more function which which carry out sliding substances: removal
An electrostatic charge with chastichek a powder or Granulate, that also
Improves their flowability. For this purpose use talc, stearaty, aeroforces.
These substances are expedient for entering into structure tabletiruemyh weights in
vysokodispersnom a status. The more the degree of crushing, the is more
tabletiruemoj weights at identical quantity they can cover a surface.
As talc and stearaty are waterproof sliding substances,
They complicate penetration of digestive liquids into porous structure
Tablets that worsens her raspadaemost. For tablets not prolonged
Actions it is undesirable, since at a therapeutic dosage medicinal
Slow liberation of the last will not provide substances therapeutic
Their concentration in blood, therefore decrease in the maintenance of sliding substances for
The bill of increase of their dispersiveness allows to improve quality of finished goods.
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